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Department of Cardiothoracic Surgery
Research

Evaluation of intraoperative CO2 insufflation on neurocognitive outcome following open heart surgery.

  • Neurocognitive dysfunction still continues to worsen the postoperative quality of life in patients who have undergone open heart surgery despite vast improvements in the surgical, anesthetic & postoperative management. This study aims to evaluate the efficacy of intraoperative field flooding technique with carbon dioxide in displacing intracardiac air in patients undergoing open heart surgery & thus reducing the gaseous emboli which have been implicated as the major cause of postoperative neurocognitive dysfunction. This study, which is nearing completion, has been done in nearly 300 adults patient has shown that carbon dioxide insufflations routinely can definitely bring down the incidence of neurocognitive dysfunction.

Evaluation of anti-calcification treatment of bovine jugular vein for use as a valved right ventricular outflow tract conduit in complex congenital heart disease.

  • An in-vivo animal study to enable assessment for one of the parameters of suitability of bovine jugular vein as RVOT conduit in CCHD. Anticalcification agents are used for treatment of bovine jugular vein for 10 days and  are injected subcutaneously in a guinea pig for a wk. Subsequently explanted for evaluation after 2 wks to assess the degree of calcification

Evaluation of the efficacy of HTK solution for myocardial protection in cardiac surgery.

  • Evaluates the efficacy of HTK (Histidine-Ketoglutarate) solution as single dose cardioplegia and compare the results with conventional multi dose hyperkalemic blood cardioplegia. 50 patients (25 adult and 25 paediatric) planned to undergo cardiac surgery will be the subjects of the study and would be randomly assigned to two equal groups (HTK Gp and Conv CPG GP). During and after the surgery, the patients would be monitored closely. Aortic cross-clamp time, CPB time, postoperative inotropic requirement, extubation time and ICU stay would be recorded. Lab measurement of serum enzymes indicative of myocardial cell damage like creatine kinase (CK) and its MB fraction (CK MB). Troponin I and lactate levels would be done during and post surgery at regular intervals. A 12 lead ECG would be recorded prior to surgery and subsequent intervals postop. These results of the two groups would be compared and evaluated statistically.